Vilanterol Impurity 28 CAS 503069-68-9 (free base)
| CAS No. | 503069-68-9 (free base) |
| Molecular Formula | C24H33Cl2NO5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vilanterol Impurity 28 (CAS 503069-68-9 (free base), C24H33Cl2NO5C20H16O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Vilanterol Impurity 28 (C24H33Cl2NO5C20H16O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 774.78 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H33Cl2NO5 C20H16O2 |
| Molecular Weight | 774.78 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Vilanterol Standards
- Vilanterol impurity 90 (CAS 1027529-99-2)
- Vilanterol Impurity 54 HCI (CAS 1463889-71-5)
- Vilanterol Impurity 88 (CAS 1582675-85-1)
- Vilanterol Impurity 5 (CAS 1582675-85-1（free base）)
- Vilanterol-d4 Triphenylacetate (CAS 2021249-10-3(non-labelled))
- Vilanterol Impurity 15 (CAS 208925-08-0)
- Vilanterol Impurity 86 (CAS 2514696-13-8)
- Vilanterol Impurity 10 HCl (CAS 2514696-13-8（free base）)
Recommended Standards
- Clobetasone Butyrate Impurity 7 (CAS CATO-C4X-35397)
- Resmetirom Impurity 99 (CAS CATO-C4X-291299)
- Nitroso Perindopril EP impurity K (CAS CATO-C4X-125249)
- N-[(1R,2R)-2-(Dimethylamino)cyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl]thiourea (CAS 1173373-71-1)
- Methyl 2-(2-aminooxazol-5-yl)acetate (CAS 878375-87-2)
- 2-Methoxy-2-(5-methylthiophen-2-yl)acetonitrile (CAS 1484301-61-2)
- N-(4-Aminophenyl)-4-methylbenzenesulfonamide (CAS 6380-08-1)
- (S)-Dimethyl 2-hydroxypentanedioate (CAS 55094-97-8)
- 4-(1-Methyl-1h-imidazol-2-yl)butanoic acid (CAS 1369002-45-8)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
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